Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Multiple Endocrine Neoplasia Type 1 Associated with Spinal Ependymoma
Hisayoshi KATOIsao UCHIMURAMasaharu MOROHOSHIKazuhiko FUJISAWAYasushi KOBAYASHIFujio NUMANONarihide GOSEKIMitsuo ENDOAtsuhisa TAMURAChikao NAGASHIMA
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1996 Volume 35 Issue 4 Pages 285-289

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Abstract

A 51-year-old man was hospitalized with a gait disturbance and hypoesthesia below the level of his chest. These symptoms were due to a spinal tumor which was surgically resected and identified as an ependymoma. Additionally, the patient had hypercalcemia and a family history of insulinoma. An endocrine evaluation revealed parathyroid hyperplasia and a pancreatic islet cell tumor. Magnetic resonance imaging disclosed a pituitary microadenoma. He was diagnosed with spinal ependymoma and multiple endocrine neoplasia type 1 (MEN 1). A review of the literature revealed that chromosome 11q13 abnormalities have been reported in both ependymoma and MEN 1. We discuss the pathogenesis of these diseases.
(Internal Medicine 35: 285-289, 1996)

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