Bronchiolitis Obliterans Organizing Pneumonia Associated with Systemic Lupus Erythematosus with Antiphospholipid Antibody

Fumio OTSUKA; Tetsuki AMANO; Naoko HASHIMOTO; Maki TAKAHASHI; Nobuhiko HAYAKAWA; Hirofumi MAKING; Zensuke OTA; Toshio OGURA

doi:10.2169/internalmedicine.35.341

Fumio OTSUKA, Tetsuki AMANO, Naoko HASHIMOTO, Maki TAKAHASHI, Nobuhiko HAYAKAWA, Hirofumi MAKING, Zensuke OTA, Toshio OGURA

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Keywords: connective tissue disease, interstitial pneumonia, transbronchial lung biopsy (TBLB), Masson body, antiphospholipid syndrome (APS)

JOURNAL FREE ACCESS

1996 Volume 35 Issue 4 Pages 341-344

DOI https://doi.org/10.2169/internalmedicine.35.341

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Abstract

Bronchiolitis obliterans organizing pneumonia (BOOP) is a pathologic entity characterized by the formation of fibrous tissue plugs within terminal bronchioles and alveolar ducts. Although BOOP has been associated with several connective tissue disorders, there are rare reports of BOOP in patients with systemic lupus erythematosus (SLE). We present a patient with SLE accompanying antiphospholipid antibody who developed recurrent respiratory symptoms and radiographic abnormalities. The diagnosis of BOOP was confirmed by transbronchial lung biopsy. This case suggests that not only SLE, but also the presence of antiphospholipid antibody, may be associated with the development of BOOP.
(Internal Medicine 35: 341-344, 1996)

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