Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Serum Levels of Soluble Fas/APO-1 Receptor in Human Retroviral Infection and Associated Diseases
Shimeru KAMIHIRAYasuaki YAMADAYouichi HIRAGATATosiyuki YAMAGUCHIKohichi IZUMIKAWAYuzi MATSUOKazuyuki SUGAHARAKazuto TSURUTASunao ATOGAMIKunihiro TSUKASAKITakahiro MAEDAMasao TOMONAGA
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1997 Volume 36 Issue 3 Pages 166-170

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Abstract

Fas/APO-1 mediates apoptosis via Fas and Fas ligand transduction. Recently, a soluble form of Fas (sFas) was described which seems to be functionally implicated in the Fas signal system, suggesting a relationship between some disorders and sFas function. We measured sFas-levels in sera from normal controls and patients with disorders linked to human retroviral infection of human immunodeficiency virus (HIV) and human T-cell leukemia virus type-1 (HTLV-1). The sFas level of normal controls. HTLV-1 carriers seronegative for HIV, and patients with HTLV-1 associated myelopathy/tropical paraparesis (HAM/TSP), adult T-cell leukemia (ATL), and AIDS was 1.62±0.49, 1.90±0.49, 2.00±0.59, 3.32±2.05, and 3.06±0.92 ng/ml, respectively. Although the level of sFas in patient groups with HAM/TSP, ATL, and AIDS was significantly high in comparison to that of normal controls (p<0.01), the individual values were highly variable within the groups. The sFas level was statistically correlated to the soluble interleukin-2 receptor (sIL-2R) level, as well as to cells expressing membrane Fas (mFas), indicating the same cellular origin. In some ATL cases, however, serum sFas levels and mFas expression density on leukemic T-cells were discrepant, with especially high levels of the soluble form and a lack of expression of the membrane form observed in 2 cases. sFas detection could serve as a putative marker for active diseases in patients with ATL and AIDS.
(Internal Medicine 36: 166-170, 1997)

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