Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Reversibly Increased Lymphocyte Response to Mitogens in a Young Man with Isolated Adrenocorticotropic Hormone Deficiency
Mari KIMURAShun-ichi TANAKATadashi YAMAKAWARan TACHIHARATatsuya SAITOHYumiko YAMAGUCHIHisahiko SEKIHARA
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1997 Volume 36 Issue 3 Pages 194-197

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Abstract

A 21-year-old man with isolated adrenocorticotropic hormone (ACTH) deficiency complained of loss of consciousness in association with hypoglycemia. Both plasma ACTH and cortisol levels were low and failed to respond to corticotropin-releasing hormone (CRH) stimulation. The patient also showed abnormal findings in hematological examination, such as neutropenia and anemia with lymphocytosis, activity of coagulation factors, and electroencephalography (EEC). Furthermore, mitogen-induced lymphocyte proliferation was increased. After successful replacement therapy with hydrocortisone 15 rag/day, most of these abnormalities including the lymphocyte proliferation were fully restored.
(Internal Medicine 36:194-197, 1997)

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