Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Diffuse Alveolar Hemorrhage Associated with Proteinase 3-Specific Anti-Neutrophil Cytoplasmic Antibodies
Masayuki KIKAWADAYuichi ICHINOSEKazushige MINEMURAAkira KUNISAWAHiroshi KUSUMOTOSeiichi OKABEMakoto YONEMARUMakoto OGURAToshiyuki NAKAOYoshiro EBIHARAKeisuke TOYAMA
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1997 Volume 36 Issue 6 Pages 430-434

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Abstract

A 31-year-old man was referred to our hospital for the management of progressive diffuse alveolar hemorrhage associated with renal dysfunction. Leukocytoclastic vasculitis was shown by skin biopsy and crescentic glomerulonephritis was also detected, in addition to positivity for proteinase 3-specific anti-neutrophil cytoplasmic antibodies (PR3-ANCA). The patient was diagnosed as a rare case of PR3-ANCA-positive pulmonary-renal vasculitic syndrome without granulomatous lesions. There was a good response to combination therapy with steroids and cyclophosphamide.
(Internal Medicine 36: 430-434, 1997)

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