Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Mechanism of Increased Serum Cytokeratin 19 Fragment Levels in Patients with Diabetic Nephropathy as a Model of Chronic Renal Failure
Kosuke KASHIWABARAKoji KISHIHiroyuki NAKAMURAHisanaga YAGYUKatsuyuki KOBAYASHIOsamu WATANABETakeshi MATSUOKA
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1998 Volume 37 Issue 11 Pages 917-921

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Abstract

We examined serum and urinary cytokeratin 19 fragment (CYFRA 21-1) levels in patients with diabetic nephropathy as a model of chronic renal failure, to investigate the mechanism of increased serum CYFRA 21-1 levels in chronic renal failure. Serum and urinary CYFRA 21-1 levels in non-insulin-dependent diabetes mellitus (NIDDM) patients with abnormal urinary immunoglobulin G (IgG) levels (>1.1 mg/g • Cr, n=126) were higher than those with normal urinary IgG levels. In NIDDM patients with normal urinary IgG levels (n=81); the urinary albumin or transferrin levels were not related to serum or urinary CYFRA 21-1 levels. We speculate that the increased serum CYFRA 21-1 levels contribute to metabolic abnormality in the kidney itself rather than the decreased urinary excretion per se, and that increased urinary CYFRA 21-1 levels are found in advanced cases of diabetic nephropathy with destruction of the size barrier.
(Internal Medicine 37: 917-921, 1998)

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