Early Diagnosis of Central Nervous System Aspergillosis with Combination Use of Cerebral Diffusion-weighted Echo-planar Magnetic Resonance Image and Polymerase Chain Reaction of Cerebrospinal Fluid

Masahiro KAMI; Ichiro SHIROUZU; Kinuko MITANI; Seishi OGAWA; Tomoko MATSUMURA; Yoshinobu KANDA; Tomohiko MASUMOTO; Toshiki SAITO; Yuji TANAKA; Kazuhiro MAKI; Hiroaki HONDA; Shigeru CHIBA; Kuni OHTOMO; Hisamaru HIRAI; Yoshio YAZAKI

doi:10.2169/internalmedicine.38.45

Masahiro KAMI, Ichiro SHIROUZU, Kinuko MITANI, Seishi OGAWA, Tomoko MATSUMURA, Yoshinobu KANDA, Tomohiko MASUMOTO, Toshiki SAITO, Yuji TANAKA, Kazuhiro MAKI, Hiroaki HONDA, Shigeru CHIBA, Kuni OHTOMO, Hisamaru HIRAI, Yoshio YAZAKI

Author information

Masahiro KAMI
The Department of Hematology and Oncology, Tokyo University
Ichiro SHIROUZU
The Department of Radiology, Tokyo University
Kinuko MITANI
The Department of Hematology and Oncology, Tokyo University
Seishi OGAWA
The Department of Hematology and Oncology, Tokyo University
Tomoko MATSUMURA
The Department of Hematology and Oncology, Tokyo University
Yoshinobu KANDA
The Department of Hematology and Oncology, Tokyo University
Tomohiko MASUMOTO
The Department of Radiology, Tokyo University
Toshiki SAITO
The Department of Hematology and Oncology, Tokyo University
Yuji TANAKA
The Department of Hematology and Oncology, Tokyo University
Kazuhiro MAKI
The Department of Hematology and Oncology, Tokyo University
Hiroaki HONDA
The Department of Hematology and Oncology, Tokyo University
Shigeru CHIBA
The Department of Hematology and Oncology, Tokyo University
Kuni OHTOMO
The Department of Radiology, Tokyo University
Hisamaru HIRAI
The Department of Hematology and Oncology, Tokyo University
Yoshio YAZAKI
The Department of Hematology and Oncology, Tokyo University

Keywords: polymerase chain reaction of the cerebrospinal fluid (CSF-PCR), diffusion-weighted echo-planar magnetic resonance imaging (DWI), cerebral infarction, invasive aspergillosis, acute lymphoblastic leukemia

JOURNAL FREE ACCESS

1999 Volume 38 Issue 1 Pages 45-48

DOI https://doi.org/10.2169/internalmedicine.38.45

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Abstract

We treated a patient diagnosed as central nervous system (CNS) aspergillosis with the combined use of cerebral diffusion-weighted echo-planar magnetic resonance imaging (DWI) and polymerase chain reaction of the cerebrospinal fluid (CSF-PCR). DWI, a cutting-edge imaging modality to reveal the earliest changes of cerebral infarction, detected cerebral fungal embolization when the conventional computed tomographic scan and magnetic resonance imaging failed to reveal it. CSF-PCR demonstrated the presence of Aspergillus-speciflc DNA in the specimen, when the conventional examination and culture of CSF were nonspecific or negative. These diagnostic methods could be useful in the early diagnosis of CNS aspergillosis.
(Internal Medicine 38:45-48, 1999)

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