Relationship between Glycosylated Hemoglobin and the Prevalence of Proteinuria in Japanese Men

Abstract

A total of 5, 174 Japanese men were included in a cross-sectional study to examine the relationship between the glycated hemoglobin (HbA_lc) level and the prevalence of proteinuria as determined using a reagent strip. The prevalence of proteinuria rose significantly at HbA_lc levels above 5.9%, whereas no relationship was observed at HbA_lc levels below 5.9%. Multiple logistic regression analysis showed that blood pressure and a family history of diabetes were independent factors associated with proteinuria in subjects with a HbA_lc below 5.9% who were not under medication for diabetes. In contrast, HbA_lc, obesity and smoking were associated with proteinuria in subjects who were under medication for diabetes and/or have a HbA_lc above 5.9%. These findings suggest that maintaining a HbA_lc level below 5.9%, non-smoking and a standard body weight may reduce the prevalence of proteinuria in Japanese men. Healthy life-style and standard body weight are especially important for subjects with a family history of diabetes.
(Internal Medicine 38: 6-11, 1999)