Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Therapy-related Megakaryoblastic Leukemia with Pituitary Involvement Following Treatment for Non-Hodgkin's Lymphoma
Takashi SAITOHKohji MORIMOTOTakao KUMAGAIMinoru SAIKIMegumi TANAKAShingo AIKAWAIsao TSUBOIUmihiko SAWADATakashi HORIE
Author information
JOURNAL FREE ACCESS

1999 Volume 38 Issue 11 Pages 904-909

Details
Abstract

A case of a 66-year-old Japanese man developed therapy-related megakaryoblastic leukemia with pituitary involvement after chemotherapy for non-Hodgkin's lymphoma. Alkylating agents had been administered for the treatment of non-Hodgkin's lymphoma and 6 years later, megakaryoblastic leukemia with myelofibrosis and myelodysplasia developed. The blast cells expressed CD41, and immature antigens also. These findings were compatible with therapy-related megakaryoblastic leukemia. An autopsy revealed blast-cell infiltration into multiple organs including the posterior pituitary lobe. Therapy-related megakaryoblastic leukemia is very rare, and pituitary involvement may be associated with immaturity of blast cells.
(Internal Medicine 38: 904-909, 1999)

Content from these authors
© The Japanese Society of Internal Medicine
Previous article Next article
feedback
Top