Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
A Probable Relationship between an Endogenous Digitalis-Like Substance and Concentric Cardiac Hypertrophy in Primary Aldosteronism
Toshio SHIMADAYukihiro NAGASAKAYutaka ISHIBASHIHironori TSUKIHASHIYo MURAKAMIKazuya SANOKazuaki TANABEYoshitomi HIROYUKIRinji MURAKAMIShigefumi MORIOKA
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1999 Volume 38 Issue 8 Pages 655-659

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Abstract

A 44-year-old woman was admitted to our hospital due to severe hypertension. An electrocardiogram (ECG) and an echocardiogram showed severe left ventricular hypertrophy. Her plasma aldosterone level was elevated. Magnetic resonance imaging revealed a small mass in the right adrenal gland. Before removal of the tumor, plasma endogenous digitalis-like substance (EDLS) levels were elevated. After removal of the tumor, EDLS levels quickly returned to the normal level. A series of echocardiograms and ECGs over a 6- year period after removal of the tumor showed marked regression of cardiac hypertrophy. These findings suggest that EDLS may be closely related to the development of concentric cardiac hypertrophy in primary aldosteronism.
(Internal Medicine 38: 655-659, 1999)

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© The Japanese Society of Internal Medicine
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