Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Simultaneous Macroamylasemia and Macrolipasemia in a Patient with Systemic Lupus Erythematosus in Remission
Hiroyuki GOTOHideki WAKUIAtsushi KOMATSUDAHirokazu IMAIAkira B. MIURAKiyotaka FUJITA
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2000 Volume 39 Issue 12 Pages 1115-1118

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Abstract

We report the fourth case of simultaneous macroamylasemia and macrolipasemia. A 39-year-old woman had been treated for systemic lupus erythematosus from 1982 to 1993. She was found to have an unexplained increase in serum amylase and lipase activities since 1996. Immunoprecipitation assay showed that amylase was bound to IgA2-κ and IgA1-κ (IgA2>IgAl), whereas lipase was bound to IgAl-κ. During a follow-up period up to December 1999, the patient did not develop any additional autoimmune or lymphoproliferative disorders. In the situation of atypical clinical features associated with hyperamylasemia and hyperlipasemia, the possibility of macroenzymes should be considered.
(Internal Medicine 39:1115-1118, 2000)

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© The Japanese Society of Internal Medicine
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