Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Regression of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma with Reduced Telomerase Activity after Eradication of Helicobacter pylori
Wataru MIWAKyutaro TOYAMAKazuhisa KAMATATakashi WATANABEYukashi TAKEYOSHIKiyoharu WATANABEJiro HONMAMakoto NOTOMasaaki KANAYAMAHisashi HISATOMIYoji NAGASHIMA
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2000 Volume 39 Issue 4 Pages 300-304

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Abstract

Recently, telomerase activity has been demonstrated in a large number of malignant tumors whereas its activity is not detected in most normal somatic cells suggesting its role in the immortalization process. Here we report the first investigation of telomerase activity in a case of gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Elevated telomerase activity was detected in biopsy specimens of the lymphoma. After eradication of Helicobacter pylori, the level of telomerase activity returned to normal with histological regression of the lymphoma. The telomerase activity was associated with the disease activity of the gastric MALT lymphoma after eradication therapy in the present case.
(Internal Medicine 39: 300-304, 2000)

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© The Japanese Society of Internal Medicine
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