A Patient with Chronic Hepatitis C Who Obtained Sustained Response by Retreatment of Interferon after Decrease of Viral Load and Mutation in Interferon Sensitivity Determining Region

Kazumasa WATANABE; Kentaro YOSHIOKA; Yasuyuki TERAZAWA; Makoto KOBAYASHI; Masatoshi ISHIGAMI; Motoyoshi YANO; Akihiko FUJI; Masaki HATTORI; Shinichi KAKUMU

doi:10.2169/internalmedicine.40.489

Kazumasa WATANABE, Kentaro YOSHIOKA, Yasuyuki TERAZAWA, Makoto KOBAYASHI, Masatoshi ISHIGAMI, Motoyoshi YANO, Akihiko FUJI, Masaki HATTORI, Shinichi KAKUMU

Author information

Kazumasa WATANABE
the Third Department of Internal Medicine, Nagoya University School of Medicine
Kentaro YOSHIOKA
the Third Department of Internal Medicine, Nagoya University School of Medicine
Yasuyuki TERAZAWA
the Third Department of Internal Medicine, Nagoya University School of Medicine
Makoto KOBAYASHI
the Third Department of Internal Medicine, Nagoya University School of Medicine
Masatoshi ISHIGAMI
the Third Department of Internal Medicine, Nagoya University School of Medicine
Motoyoshi YANO
the Third Department of Internal Medicine, Nagoya University School of Medicine
Akihiko FUJI
Holy Spirit Hospital
Masaki HATTORI
the First Department of Internal Medicine, Aichi Medical University
Shinichi KAKUMU
the First Department of Internal Medicine, Aichi Medical University

Keywords: direct sequencing, HCV-J, PCR

JOURNAL FREE ACCESS

2001 Volume 40 Issue 6 Pages 489-492

DOI https://doi.org/10.2169/internalmedicine.40.489

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Abstract

A 44-year-old man with chronic hepatitis C received three courses of interferon (IFN) therapy. HCV genotype was 1b, viral load was 1, 200 kcopies/ml and interferon sensitivity determining region (ISDR) was the intermediate type before the 1st IFN therapy. The 1st and 2nd IFN therapies resulted in failure to yield a sustained response. Seven years after from the 1st therapy, viral load had decreased to 15 kcopies/ml and ISDR had changed to mutant type. The 3rd IFN therapy yielded sustained response. Thus, we should consider retreatment with IFN when a decrease of the viral load and change of ISDR to mutant type are observed.
(Internal Medicine 40: 489-492, 2001)

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