Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Hypertrophic Pulmonary Osteoarthropathy Associated with Non-small Cell Lung Cancer Demonstrated Growth Hormone-Releasing Hormone by Immunohistochemical Analysis
Katsuhiko MITORiichiroh MARUYAMAYoshiko UENISHIKazuhiro ARITAHiroshi KAWANOKenji KASHIMAMasaru NASU
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2001 Volume 40 Issue 6 Pages 532-535

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Abstract

Hypertrophic pulmonary osteoarthropathy (HPO) associated with non-small cell lung cancer in a 58-year-old man was accompanied by an elevated serum level of growth hormone (GH). HPO rapidly disappeared after resection of the primary tumor and the elevation of serum GH was resolved. Immunohistochemically the tumor contained growth hormone-releasing hormone (GHRH) but not GH. These findings suggest that the high serum GH level due to ectopic GHRH production in the tumor, was a contributing factor in HPO. This is the second reported case of non-small cell lung cancer which was immunohistochemically positive for GHRH associated with HPO.
(Internal Medicine 40: 532-535, 2001)

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© The Japanese Society of Internal Medicine
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