Primary Adenosquamous Carcinoma of the Liver Which Produces Granulocyte-Colony-Stimulating Factor and Parathyroid Hormone Related Protein: Association with Leukocytosis and Hypercalcemia

Tatsuhiko HAYASHI; Akira MIZUKI; Takuya YAMAGUCHI; Tasuku HASEGAWA; Takamu KUNIHIRO; Nobuhiro TSUKADA; Kentaro MATSUOKA; Hideki ORIKASA; Kazuto YAMAZAKI

doi:10.2169/internalmedicine.40.631

Tatsuhiko HAYASHI, Akira MIZUKI, Takuya YAMAGUCHI, Tasuku HASEGAWA, Takamu KUNIHIRO, Nobuhiro TSUKADA, Kentaro MATSUOKA, Hideki ORIKASA, Kazuto YAMAZAKI

Author information

Tatsuhiko HAYASHI
the Department of Internal Medicine, Tokyo Saiseikai Central Hospital
Akira MIZUKI
the Department of Internal Medicine, Tokyo Saiseikai Central Hospital
Takuya YAMAGUCHI
the Department of Internal Medicine, Tokyo Saiseikai Central Hospital
Tasuku HASEGAWA
the Department of Internal Medicine, Tokyo Saiseikai Central Hospital
Takamu KUNIHIRO
the Department of Internal Medicine, Tokyo Saiseikai Central Hospital
Nobuhiro TSUKADA
the Department of Internal Medicine, Tokyo Saiseikai Central Hospital
Kentaro MATSUOKA
the Department of Pathology, Tokyo Saiseikai Central Hospital
Hideki ORIKASA
the Department of Pathology, Tokyo Saiseikai Central Hospital
Kazuto YAMAZAKI
the Department of Pathology, Tokyo Saiseikai Central Hospital

Keywords: primary liver tumor, paraneoplastic syndrome, cytokine

JOURNAL FREE ACCESS

2001 Volume 40 Issue 7 Pages 631-634

DOI https://doi.org/10.2169/internalmedicine.40.631

Details

Abstract

A 55-year-old man was admitted to our hospital with fever and vomiting. Abdominal computed tomography (CT) revealed multiple low density masses in the liver. A diagnosis of primary adenosquamous carcinoma of the liver was confirmed by histological examination of a necropsy specimen. The present case showed leukocytosis and hypercalcemia with high levels of serum granulocyte-colony-stimulating factor (G-CSF) and parathyroid hormone related protein (PTHrP). Recent studies have shown that G-CSF and PTHrP are responsible for the paraneoplastic syndromes with leukocytosis and hypercalcemia. The tumor cells demonstrated positive cytoplasmic immunohistochemistry staining with anti-G-CSF and anti-PTHrP antibodies. This result suggested that the tumor produced G-CSF and PTHrP.
(Internal Medicine 40: 631-634, 2001)

Corresponding author

Register with J-STAGE for free!