Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Massive Rhabdomyolysis and Acute Renal Failure after Acetonitrile Exposure
Kazuhiko MURAKIYasushi INDUEItsuro OHTAKaori KONDOYasutoshi MATAYOSHIToshiaki KAMEI
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2001 Volume 40 Issue 9 Pages 936-939


A case of systemic rhabomyolysis after acetonitrile exposure is reported. A 35-year-old previously healthy man suffered from vomiting, convulsion and consciousness loss 15 hours after exposure to acetonitrile. Since acetonitrile is known to be metabolized into cyanide, antidote therapy against cyanide poisoning was given. On admission, pain and all-over muscle swelling were marked. Although the initial therapy was effective, rhabdomyolysis and then acute renal failure developed. Renal function improved very slowly after six weeks of hemodialysis, but atrophy of the muscles remained. The rhabdomyolysis may have been caused by toxicity of the cyanide itself in combination with hypoxia and convulsion.
(Internal Medicine 40: 936-939, 2001)

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