Anti-Ku Antibody-Positive Scleroderma-Dermatomyositis Overlap Syndrome Developing Graves' Disease and Immune Thrombocytopenic Purpura

Nozomu KAMEI; Kiminori YAMANE; Yasuyo YAMASHITA; Shuhei NAKANISHI; Hiroshi WATANABE; Rumi FUJIKAWA; Keiko HIYAMA; Shinichi ISHIOKA; Giro MENDOZA; Nobuoki KOHNO

doi:10.2169/internalmedicine.41.1199

Nozomu KAMEI, Kiminori YAMANE, Yasuyo YAMASHITA, Shuhei NAKANISHI, Hiroshi WATANABE, Rumi FUJIKAWA, Keiko HIYAMA, Shinichi ISHIOKA, Giro MENDOZA, Nobuoki KOHNO

Author information

Nozomu KAMEI
The Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Kiminori YAMANE
The Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Yasuyo YAMASHITA
The Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Shuhei NAKANISHI
The Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Hiroshi WATANABE
The Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Rumi FUJIKAWA
The Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Keiko HIYAMA
The Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
Shinichi ISHIOKA
Ishioka Clinic
Giro MENDOZA
National Institute of Pulmonary and Enviromental Diseases
Nobuoki KOHNO
The Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University

Keywords: thrombocytopenia, anti-thyroid drug, natural killer Tcell

JOURNAL FREE ACCESS

2002 Volume 41 Issue 12 Pages 1199-1203

DOI https://doi.org/10.2169/internalmedicine.41.1199

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Abstract

Graves' disease (GD) has been reported to be frequently complicated with other autoimmune diseases. However, it is rarely complicated with scleroderma-polymyositis overlap syndrome. Recently, we encountered a 35-year-old woman who developed GD and immune thrombocytopenic purpura during follow-up observation of scleroderma-dermatomyositis overlap syndrome. Platelet counts recovered after high-dose γ-globulin therapy and bolus methylprednisolone therapy. The present case is the first report of a combination of scleroderma, dermatomyositis, GD, and immune thrombocytopenic purpura. The patient was anti-Ku antibody-positive and had relatively low natural killer T cell counts, both of which might contribute to the complication of multiple autoimmune diseases.
(Internal Medicine 41: 1199-1203, 2002)

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