Usefulness of the Modified Lavage Technique of Bingisser and KL-6 Monitoring in a Patient with Pulmonary Alveolar Proteinosis

Nobuhisa ISHIKAWA; Keiichi KONDO; Tetsuya OGURI; Masakazu KAMITSUNA; Joji SAKURAI; Kazunori FUJITAKA; Masahiro YAMASAKI; Hiroyuki MAEDA; Takeshi ISOBE; Nobuoki KOHNO

doi:10.2169/internalmedicine.41.381

Nobuhisa ISHIKAWA, Keiichi KONDO, Tetsuya OGURI, Masakazu KAMITSUNA, Joji SAKURAI, Kazunori FUJITAKA, Masahiro YAMASAKI, Hiroyuki MAEDA, Takeshi ISOBE, Nobuoki KOHNO

Author information

Nobuhisa ISHIKAWA
The Second Department of Internal Medicine, Hiroshima University Faculty of Medicine
Keiichi KONDO
The Second Department of Internal Medicine, Hiroshima University Faculty of Medicine
Tetsuya OGURI
The Second Department of Internal Medicine, Hiroshima University Faculty of Medicine
Masakazu KAMITSUNA
The Second Department of Internal Medicine, Hiroshima University Faculty of Medicine
Joji SAKURAI
The Second Department of Internal Medicine, Hiroshima University Faculty of Medicine
Kazunori FUJITAKA
The Second Department of Internal Medicine, Hiroshima University Faculty of Medicine
Masahiro YAMASAKI
The Second Department of Internal Medicine, Hiroshima University Faculty of Medicine
Hiroyuki MAEDA
The Department of Respiratory Division, Hiroshima Prefecture Hospital
Takeshi ISOBE
The Second Department of Internal Medicine, Hiroshima University Faculty of Medicine
Nobuoki KOHNO
The Second Department of Internal Medicine, Hiroshima University Faculty of Medicine

Keywords: krebs der Lungen-6, MUC1, epithelial lining fluid

JOURNAL FREE ACCESS

2002 Volume 41 Issue 5 Pages 381-385

DOI https://doi.org/10.2169/internalmedicine.41.381

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Abstract

A 48-year-old man diagnosed as pulmonary alveolar proteinosis (PAP) received a whole-lung lavage by the conventional lavage technique, but he failed to show any clinical or functional improvement. Therefore, we applied a modified lavage technique of Bingisser resulting in the impressive clinical and functional improvement. We measured the levels of KL-6 in bronchoalveolar lavage fluid (BALF) at selected time intervals. KL-6 levels in BALF were higher during the lavage by the modified lavage technique of Bingisser than the conventional lavage technique. We were able to verify the usefulness of the modified lavage technique of Bingisser by monitoring the levels of KL-6 in BALF. The modified lavage technique of Bingisser may be useful for PAP treatment.
(Internal Medicine 41: 381-385, 2002)

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