Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
A Primary Sjögren's Syndrome Patient with Marked Swelling of Multiple Exocrine Glands and Sclerosing Pancreatitis
Chiho AKAHANEYo-ichi TAKEIAkira HORIUCHIShigeyuki KAWAIsao NISHIMORIShu-ichi IKEDA
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2002 Volume 41 Issue 9 Pages 749-753

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Abstract

A 55-year-old man suffered from nasal obstruction, swelling of the salivary glands, and diplopia caused by markedly enlarged lacrimal glands. The diagnosis of primary Sjögren's syndrome was made by a positive Schirmer's test and nasal mucosal biopsy with severe lymphocyte infiltration. He was also found to have swelling of the whole pancreas and increased wall thickness in the common bile duct and the gall bladder. His serum was positive for an anti-carbonic anhydrase II antibody. Since carbonic anhydrase II is present in the ductal cells of various exocrine organs, this autoantibody is considered to be related to the pathogenesis of primary Sjögren's syndrome with a marked swelling of multiple exocrine organs.
(Internal Medicine 41: 749-753, 2002)

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