Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Acute Reversible Myocardial Depression Associated with Sepsis
Makoto KontaniYoshiaki IZUMIYAMiho ShimizuKeiichi YasumaAkira INADAHajime OhtaTakayuki IKEDA
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2003 Volume 42 Issue 1 Pages 60-65


A 30-year-old man was admitted to our hospital for left lobar pneumonia with septic shock. Acute left-sided heart failure became evident as sepsis developed. Echocardiography revealed diffuse severe hypokinesis of the left ventricle (LV) and a pulmonary artery catheter showed Forrester subset II hemodynamics. Along with amelioration of sepsis and decrease of the serum concentrations of tumor necrosis factor-α and interleukin-6, LV hypokinesis improved. It is suggested that the patient's heart failure may have been due to functional depression of myocardial contractility resulting from a direct effect of the cytokines towards the cardiomyocytes, the so-called "septic myocardial depression".
(Internal Medicine 42: 60-65, 2003)

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