Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Secondary Pulmonary Alveolar Proteinosis Associated with Myelodysplastic Syndrome
Tetsuro OHNISHIGen YAMADANoriharu SHIJUBOYoko TAKAGI-TAKAHASHITakayuki ITOHHiroki TAKAHASHIMasaaki SATOHHiroyuki KOBAKoh NAKATAShosaku ABE
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2003 Volume 42 Issue 2 Pages 187-190

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Abstract

A 47-year-old man, who had been diagnosed as myelodysplastic syndrome (MDS), complained of a severe cough and a high-grade fever. Chest CT disclosed scattered small nodules and ground-glass opacities with interlobular septal thickening in both lung fields and a mass lesion in the right lower lobe. Pathological findings of the ground-glass opacities and the mass lesion obtained by video-assisted thoracoscopic surgery revealed the accumulation of eosinophilic amorphous material in the alveoli and confirmed the diagnosis of pulmonary alveolar proteinosis (PAP). Autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) in sera were below sensitivity, while the GM-CSF level was elevated in bronchoalveolar lavage fluid. He was diagnosed as secondary PAP associated with MDS.
(Internal Medicine 42: 187-190, 2003)

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