Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Analysis of Risk Factors for Hepatocellular Carcinoma That is Negative for Hepatitis B Surface Antigen (HBsAg)
Seika SHIMADARyoichi AlZAWAHiroshi ABESatoshi SUTOYoshinari MlYAKAWAYoshio AlZAWA
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2003 Volume 42 Issue 5 Pages 389-393


Objective To clarify risk factors for hepatocellular carcinoma (HCC) other than hepatitis B surface antigen (HBsAg).
Patients and Methods We investigated serum HBV-DNA and other factors in 146 patients with liver cirrhosis (LC) or HCC who were HBsAg negative. We analyzed the clinical background of the patients, status of hepatitis B (HBV) viral markers and platelet count as well as the presence of an HBV-DNA fragment by PCR and elucidated risk factors for HCC generation using a logistic regression model.
Results Among ten factors, we determined that four represented a significant risk for HBsAg negative HCC: male gender, total alcohol consumption, total cigarettes smoked, and the presence of an HBV-DNA fragment. Multivariate analysis showed that among the four factors, the HBV-DNA fragment was an independent factor associated with HCC.
Conclusion The presence of an HBV-DNA fragment irrespective of the status of antibodies to either HBsAg (anti-HBs) or hepatitis B core antigen (anti-HBc) is a pivotal factor associated with the development of HCC.
(Internal Medicine 42: 389-393, 2003)

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