Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Spontaneous Remission of a Massive CNS Inflammation with Eosinophilic Infiltrate
Yoshiko TAMARUMayumi NAKASHITAHidefumi ITORyosuke OKUMURASadayuki MATSUMOTOTerukuni IMAI
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2003 Volume 42 Issue 5 Pages 424-427


We report a case of spontaneous remission of a massive CNS lesion with eosinophilic infiltrate. This 69-yearold man had eosinophilia without any systemic disorder or laboratory evidence of the most common causes of hypereosinophilia. MRI of the brain suggested an infiltrating neoplasm, but histological examination of a needle biopsy specimen failed to show evidence of a neoplasm. Instead, the tissue demonstrated rarefaction and gliosis with striking perivascular and parenchymal infiltrates of eosinophils. The MRI abnormality and eosinophilia disappeared spontaneously. We speculate that eosinophil-derived neurotoxins might have been the cause of the transient CNS disorder observed in this patient.
(Internal Medicine 42: 424-427, 2003)

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