Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Adult Onset Anaphylactoid Purpura with Severe Gastrointestinal Involvement
Kazumi OSHIMANoriaki IINONatsue SASAKINaoki TAKAHASHIYoshinari TANABESatoshi ITOMitsuhiro UENOShin-ichi NISHIHiroki TSUKADAIchiei NARITAGo HASEGAWAEiichi SUZUKIFumitake GEIYO
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2003 Volume 42 Issue 5 Pages 436-442

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Abstract

We treated a case of adult-onset severe-form anaphylactoid purpura. This case had been diagnosed as anaphylactoid purpura pathologically by skin biopsy. However, his clinical manifestations were atypical in view of complicated massive gastrointestinal hemorrhage. Intensive therapy including corticosteroid and cyclophosphamide transiently improved his condition. Nevertheless, the beta-D-glucan value in peripheral blood was gradually elevated. Prophylactic use of fluconazole failed to prevent contraction of invasive mycosis. Finally, he suddenly suffered from diffuse cerebral hemorrhage. Postmortem examination revealed systemic invasive aspergillosis as the cause of death.
(Internal Medicine 42: 436-442, 2003)

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