A Patient with Primary Biliary Cirrhosis Complicated with Slowly Progressive Insulin-dependent Diabetes Mellitus

Hiroki NAKASONE; Kazushi KINJO; Masaaki YAMASHIRO; Tsukasa KAMIYAMA; Sakiko KAMIYAMA; Hitoshi MlYAZATO; Tatsuhiko MATSUSHITA; Yukihiro ARAKAWA; Takeharu OHSHIRO; Shiyu TOMA; Kiyoharu CHINEN; Masato YAMASHIRO; Masatake MIYAGI; Tomoko MAKISHI; Akira HOKAMA; Hiroshi SAKUGAWA; Fukunori KINJO; Atsushi SAITO

doi:10.2169/internalmedicine.42.496

Hiroki NAKASONE, Kazushi KINJO, Masaaki YAMASHIRO, Tsukasa KAMIYAMA, Sakiko KAMIYAMA, Hitoshi MlYAZATO, Tatsuhiko MATSUSHITA, Yukihiro ARAKAWA, Takeharu OHSHIRO, Shiyu TOMA, Kiyoharu CHINEN, Masato YAMASHIRO, Masatake MIYAGI, Tomoko MAKISHI, Akira HOKAMA, Hiroshi SAKUGAWA, Fukunori KINJO, Atsushi SAITO

Author information

Hiroki NAKASONE
The Okinawa Kenritsu Hokubu Hospital
The First Department of Internal Medicine, University of the Ryukyus
Toronto General Hospital, Multi Organ Transplant Program
Kazushi KINJO
The Okinawa Kenritsu Hokubu Hospital
Masaaki YAMASHIRO
The Okinawa Kenritsu Hokubu Hospital
Tsukasa KAMIYAMA
The Okinawa Kenritsu Hokubu Hospital
Sakiko KAMIYAMA
The Okinawa Kenritsu Hokubu Hospital
Hitoshi MlYAZATO
The Okinawa Kenritsu Hokubu Hospital
Tatsuhiko MATSUSHITA
The Okinawa Kenritsu Hokubu Hospital
Yukihiro ARAKAWA
The Okinawa Kenritsu Hokubu Hospital
Takeharu OHSHIRO
The Okinawa Kenritsu Hokubu Hospital
Shiyu TOMA
The Okinawa Kenritsu Hokubu Hospital
Kiyoharu CHINEN
The Okinawa Kenritsu Hokubu Hospital
Masato YAMASHIRO
The Okinawa Kenritsu Hokubu Hospital
Masatake MIYAGI
The Okinawa Kenritsu Chubu Hospital
Tomoko MAKISHI
The First Department of Internal Medicine, University of the Ryukyus
Akira HOKAMA
The First Department of Internal Medicine, University of the Ryukyus
Hiroshi SAKUGAWA
The First Department of Internal Medicine, University of the Ryukyus
Fukunori KINJO
The First Department of Internal Medicine, University of the Ryukyus
Atsushi SAITO
The First Department of Internal Medicine, University of the Ryukyus

Keywords: cirrhosis, diabetes mellitus, diagnosis

JOURNAL FREE ACCESS

2003 Volume 42 Issue 6 Pages 496-499

DOI https://doi.org/10.2169/internalmedicine.42.496

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Abstract

We report a case of primary biliary cirrhosis (PBC) complicated by slowly progressive insulin-dependent diabetes mellitus (SPIDDM). A 67-year-old woman was diagnosed as having PBC based on clinical manifestations and a positive result of anti-mitochondrial antibody. Furthermore, SPIDDM was diagnosed by her clinical course and a positive result of anti-glutamic acid decarboxylase antibody. Both PBC and SPIDDM are considered to be autoimmune diseases. However, the coexistence of PBC and SPIDDM is extremely rare. Liver cirrhosis sometimes accompanies hyperglycemia. When the etiology of liver cirrhosis is an autoimmune disorder such as PBC, SPIDDM should be considered as a cause of hyperglycemia.
(Internal Medicine 42: 496-499, 2003)

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