Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Fulminating Onset Type 1 Diabetes with Positivity for Anti-GAD Antibody and Elevated Pancreatic Exocrine Enzyme Concentrations
Toshio KAHARAToshinari TAKAMURAHitoshi ANDOMasara SAKURAITsuguhito OTATsuguho MlSAKISakae OBAMasahara IGUCHIKazutoshi KOMORIKen-ichi KOBAYASHI
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2003 Volume 42 Issue 6 Pages 517-520


A 52-year-old man was admitted to our hospital for diabetic ketoacidosis. On admission, HbA1c was 6.5%, anti-GAD antibody 10.3 U/ml, serum amylase 144 W/l, lipase 169 U/l and elastase-11, 000 ng/dl. There were no abdominal symptoms, and abdominal CT showed unremarkable findings. He was treated with intensive insulin therapy. After 1 month, urinary excretion of C-peptide was 3.8 μg/day. Serum pancreatic exocrine enzyme concentrations returned to normal after 3 months. After 10 months, anti-GAD antibody had become negative, but insulin therapy was still needed for glycemic control. This report concerns a case of autoimmune fulminating onset type 1 diabetes.
(Internal Medicine 42: 517-520, 2003)

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