Primary Bilateral Adrenal Intravascular Large B-cell Lymphoma Associated with Adrenal Failure

Ayumi FUKUSHIMA; Yosuke OKADA; Takahisa TANIKAWA; Takashi ONAKA; Aya TANAKA; Takehiro HlGASHI; Junichi TSUKADA; Yoshiya TANAKA

doi:10.2169/internalmedicine.42.609

Ayumi FUKUSHIMA, Yosuke OKADA, Takahisa TANIKAWA, Takashi ONAKA, Aya TANAKA, Takehiro HlGASHI, Junichi TSUKADA, Yoshiya TANAKA

Author information

Ayumi FUKUSHIMA
The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine
Yosuke OKADA
The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine
Takahisa TANIKAWA
The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine
Takashi ONAKA
The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine
Aya TANAKA
The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine
Takehiro HlGASHI
The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine
Junichi TSUKADA
The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine
Yoshiya TANAKA
The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine

Keywords: soluble IL-2 receptor, rapid progressive type, bilateral adrenal tumors, intravascular lymphoma, adrenal failure

JOURNAL FREE ACCESS

2003 Volume 42 Issue 7 Pages 609-614

DOI https://doi.org/10.2169/internalmedicine.42.609

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Abstract

We report a rare case of bilateral primary adrenal non-Hodgkin's lymphoma with adrenal failure. A 66-year-old woman developed symptoms of adrenal failure. The cause of adrenal failure was suspected to be malignant lymphoma based on the high levels of serum soluble interleukin-2 receptor and LDH. Bilateral adrenalectomy was performed and pathological examination showed intravascular large B-cell lymphoma (IVL). Although complete remission was achieved, recurrence occurred three months later with brain metastases. IVL should be suspected in patients with bilateral adrenal tumors who present with rapidly progressive adrenal failure.
(Internal Medicine 42: 609-614, 2003)

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