Early-phase Neutrophilia in Cigarette Smoke-induced Acute Eosinophilic Pneumonia

Keisuke MlKI; Mari MlKl; Yoichi NAKAMURA; Yoshihiro SUZUKI; Yoshio OKANO; Fumitaka OGUSHI; Yuji OHTSUKI; Takuro NAKAYAMA

doi:10.2169/internalmedicine.42.839

Keisuke MlKI, Mari MlKl, Yoichi NAKAMURA, Yoshihiro SUZUKI, Yoshio OKANO, Fumitaka OGUSHI, Yuji OHTSUKI, Takuro NAKAYAMA

著者情報

キーワード: cigarette smoke extract, interleukin 8, bronchial epithelial cell, neutrophilia, acute eosinophilic pneumonia

ジャーナルフリー

2003 年 42 巻 9 号 p. 839-845

DOI https://doi.org/10.2169/internalmedicine.42.839

詳細

抄録

Although cigarette smoking is a recognized cause of acute eosinophilic pneumonia (AEP), and an increase in eosinophils in the lung is a common occurrence in AEP, early-phase neutrophilia in AEP is not well understood. We describe three cases of cigarette smoke (menthol type)-induced AEP with neutrophilia in the lungs or blood. Increased in-vitro production of the neutrophil chemoattractant interleukin (IL)-8 by human bronchial epithelial cells (HBECs) was correlated with neutrophilia. We suggest that IL-8 released from HBECs is involved in neutrophilia in the lung in AEP, and is newly recognized as an important factor in the early phase of AEP development.
(Internal Medicine 42: 839-845, 2003)

責任著者(Corresponding author)

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