Abstract
Twenty-four patients with non-Hodgkin's lymphomas were classified histologically according to the new histological LSG classification of non-Hodgkin's lymphoma. With these 24 patients the correlation of this histological classification with clinical stage, laboratory findings and chemotherapeutic response were studied. Six of 24 cases were categorized as follicular lymphoma, 5 of which were classified as medium sized cell type and one as large cell type. Eighteen were classified diffuse lymphoma, which consisted of one with small cell type, three with medium sized cell type, another three with mixed type, seven with large cell type, three with pleomorphic type and one with lymphoblastic type. Fifteen of 24 patients were staged clinical stage III. Five were staged stage N, four of which were leukemic.
None with follicular lymphoma developed leukemic manifestation. Polyclonal hyper-gammagloburinemia was observed in four patients, of whom 2 patients were pleomorphic type. Lymphocyte counts of peripheral blood in these patients were not related to histological classification. The patients with follicular lymphoma had particularly good response to chemotherapy, and 5 of them are still alive. Eleven of 18 patients with diffuse lymphoma obtained a complete remission. Patients with mixed type and small cell type were also good responders. Of the patients with large cell type, three obtained a complete remission, three partial remission and one no response. In contrast, only one out of three patients with medium sized cell type obtained a complete remission. Fifty per cent survival time of these 18 patients with diffuse lymphomas was 15 months
