Abstract
A case of acute myelogenous leukemia (AML) with 10 years history of preleukemic phase is reported.
Twenty-seven-years-old male was diagnosed as AML because of abnormal myeloblasts in the peripheral blood and bone marrow. This patient had been examined for bone marrow because of thrombocytopenia and anemia at the age of 17, when he had hematopoietic disorder due to sideroblastic anemia retrospectively.
His chief complaint on admission was the petechiae on the face, trunk and extremities. CBC showed 330×104/mm3 of RBC, 4, 400/mm3 of WBC and 0.3×104/mm3 of platelets. The bone marrow was hypoplastic and the differential revealed 10.8% of abnormal blasts with positive peroxidase reaction.
Sideroblastogram by iron stain showed presence of the ringed sideroblasts. Chromosome analysis by G-banding method revealed abnormal pattern of 47, XY, +8, 17p+, 19p+ in 7 cells out of 10 analyzed cells. Patient died suddenly of cerebral hemorrhage after 2 months follow-up, without leukemia chemotherapy.
This case was considered as sideroblastic anemia with 10 years duration terminating in AML and had chromosome abnormality of trisomy 8.
The significance to analyze the chromosome on the unusual cases of acute leukemia with preleukemic phase is stressed.
