Abstract
Acute hemodynamic effects of Nicardipine hydrochloride (NH) were evaluated in 11 patients with ischemic heart disease unassociated with hypertension. Following control parameters were measured during cardiac catheterization, and 5 minutes after intravenous administration of NH (0.01mg/kg), the same parameters were compared with control data. The heart rate increased from 70.0±11.2 to 76.6±13.8mmHg (p<0.01). Aortic systolic and diastolic pressures decreased from 140.5±19.3 to 129.4±14.6mmHg (p<0.05) and 83.2±12.5 to 76.5±10.1mmHg (p<0.01), respectively. The mean right atrial pressure and the mean pulmonary artery pressure increased from 4.3±2.9 to 6.5±3.3mmHg (p<0.01) and 14.2±5.0 to 180±6.1 mmHg (p<0.01), respectively. The pulmonary capillary wedge pressure and left ventricular end-diastolic pressures increased from 7.6±4.2 to 9.4±4.7 mmHg (p<0.01) and 9.0±4.6 to 10.8±4.7 mmHg (p<0.05), repectively. Cardiac index increased from 2.87±0.61 to 3.33±0.86l/min/m2 (p<0.05). The systemic vascular resistance decreased from 1894±672 to 1529±576 dynes·sec·m-5 (p<0.01). However, stroke volume index, left ventricular stroke work index, pulmonary vascular resistance and double product were not significantly changed. Significant correlation between percent decrease in systemic vascular resistance and percent change in cardiac index was obtained (r=0.84). These results suggest that NH might reduce afterload, but slightly increase preload of the heart.
