Abstract
There has been a variety of discussion concerning the surgical treatment, including surgical indications and procedures, of empty sella syndrome, in particular primary one. In six patients (1 male and 5 females) aged 22-59 years, we performed surgical treatment (3 with transsphenoidal approach and 3 via craniotomy), and assessed pre- and post-operative course and findings of various examinations. Indications for surgery included visual disturbance in 1 patient, amenorrhea in 2, and intractable hedache in 3. All the patients underwent a closure of intrasellar and adjacent empty space with muscular fragments and fibrin glue. In the all patients, there was an improvement of the symptoms. The pre-operative cerebrospinal fluid pressure of all cases was within normal limits, and it is suggested that diminution or disappearance of local cerebrospinal fluid pulsation due to the closure of empty space as mentioned above brought about the favorable results. Thus, it is considered that the surgical procedures should be selected taking advantage to the closure of empty space in consideration.
