Abstract
Among the patients with acute lymphocytic leukemia treated at Sapporo National Hospital from January, 1973 through December, 1987 a total of 15 cases (10 males, 5 females, ages 0-12 years, mean 5.5 years) developed central nervous system (CNS) leukemia as a initial site of relapse. As re-induction therapy, the effects between the groups in which treatment only against CNS was given and those who received combined therapy of CNS and systemic chemotherapy were compared. In the latter group, the duration of second relapse from the time of attaining the second complete remission seemed longer than in the former group, but no statistically significant difference was revealed. This might mean that change of policy for the treatment would be essential. All three cases who received bone marrow transplantation from their siblings following after successfully reaching complete remission, have remained in event-free survival. Further follow-up and detailed observations concerning these cases are mandatory.
