2012 年 30 巻 2 号 p. 201-207
This study was designed to demonstrate the protective antioxidant effect of ascorbic acid (AsA) against electromagnetic fields (EMFs) emitted from mobile phones (MPs). Young male AsA-requiring Osteogenic Disorder Shionogi/Shi-od/od (ODS) rats were exposed to the EMF from a mobile phone for one hour a day during 30 days. Malondialdehyde (MDA) concentration, catalase (CAT) enzymatic activity and glutathione (GSH) concentration were measured in blood and liver and brain tissues. We found that the MDA concentration significantly (p < 0.05) increased as did the CAT enzymatic activity and GSH concentration (p < 0.05) in brain structure tissues when exposed to the EMF. MDA concentration and CAT enzymatic activity both and increased (p < 0.05), and GSH enzymatic activity decreased (p < 0.05) in blood and liver tissues when exposed. We concluded that one hour/day exposure to the MP-generated EMF produced some oxidative stress in blood, liver and brain and it disturbed the function of the antioxidant defensive system in young male ODS rats. These results are useful for proposing a novel evaluation method for EMF-biological interactions. However, a limitation of our study is the problem of extrapolating these results from rodents to humans, because under laboratory conditions the entire body of the ODS rats was exposed whereas for humans using MPs only the head will be exposed.