2014 Volume 90 Issue 4 Pages 138-152
An infant disorder, so-called meningitis in infancy (SCMI), was firstly reported in the 28th year of the Meiji era (1895) in Japan. Professor Ikutaro Hirai at the Kyoto University Department of Pediatrics clarified in the 12th year of the Taisho era (1923) that SCMI was a chronic lead-poisoning disease caused by white lead contaminated in the mothers’ cosmetic powder. The special regulation of white lead was stipulated in the 5th year of the Showa era (1930) and came into force in the 10th year of the Showa era (1935). We traced the history of SCMI research using the publications in the pediatric medicine in 1931-1935.: we studied 132 SCMI articles which were published in Acta Paediatrica Japonica issued in this period. These articles were classified into seven groups, namely, reviews, statistical studies, case studies, clinical observations, laboratory findings, pathology and experimental study articles. In this study, we took up and discussed the review, statistics and case study articles.