White defects(W.D.)on CCD determine the lifetime of TV camera on a manned space station. CCD is sensitive to cosmic ray compared with other semiconductor devices. Two TV cameras are terminated after 4 years operation in "MIR", even though other equipment are using after 9 years operation. The results of flight experiment and ground irradiation experiment are compared with each other to generate dark-current increasing. When pass an ion or neutron in a Pixel, it generate the "Flash" event as single event. Multi Pixel Flash phenomena is discussed.