僥骨の骨塩密度とヒト固有唾液の pH および ［K^＋］との相関に対する加齢因子の影響

抄録

An effect of aging factor was investingated on correlations between electrolyte concentrations of the human resting saliva and radial bone mineral density (BMD). The following results were obtained. Subjects, who consented to these measurements, were 164 nontreated plus control patients and 1480 steoporotic patients treated with the drug for improving bone metabolism. The BMD was measured by dual-energy X-ray absorptiometry at the distal of the radius. Salivary electrolyte and the related indices were measured by means of thin layer sampling.

1. A significant negative correlation between the radial BMD and age was confirmed in both female groups of the medicated-and nonmedicated-ones even after removal of the salivary electrolyte factors.

2. Nonsignificant correlations were found between the age vs. salivary pH₁ and △pH₁ in both female groups of the medicated-and nonmedicated-groups.

3. Although nonsignificant in the medicated female group, positive correlations between the radial BMD vs. the salivary pH₁ and △pH₁ were significant in the nonmedicated female group. Significance for these coefficients remained even after removal of the aging factor.

4. In the nonmedicated female group, there was a significant negative correlation between the radial BMD and the salivary [K⁺] even after removal of the aging factor.

5. In male groups, a significant negative correlation was found between the radial BMD and the salivary [K⁺] only in the medicated one, and this remained even after removal of aging component.