Abstract
The hyperimmunoglobulin-E (hyper-IgE) syndrome is a rare immunodeficiency characterized by recurrent infections of the skin and lungs with extremely elevated levels of IgE in the serum. We reported a case of surgical resection for pulmonary abscess from methicillin-resistant staphylococcus aureus (MRSA) due to the hyper-IgE syndrome. A 21-year-old man diagnosed with hyper-IgE syndrome at the age of 2 years was admitted because of fever and cough. On admission, the white blood cell count was 10100/mm3. The serum IgE level was extremely elevated at 21736IU/ml. MRSA was cultured from his sputum. Chest radiographs demonstrated pneumonia of the right upper lobe. Chest CT showed abscess formation in the right upper lobe. Although he was continuously treated with intravenous antibiotics, abscess formation appeared in the right lower lobe. We performed right upper lobectomy and partial resection of the S6 and S9+10 region in the right lower lobe. The postoperative course was uneventful and he was discharged on postoperative day 28. The first treatment for pulmonary infection due to the hyper-IgE syndrome is antibiotics therapy, but surgical resection should be performed for pulmonary abscess with nonfunctional space.
