A case of pleomorphic carcinoma with idiopathic interstitial pneumonia

Abstract

A 71-year-old male was diagnosed with usual interstitial pneumonia (UIP) in 1998, and had been followed without treatment. In September 2003, chest CT revealed a mass, 4cm in size, in his left lung (S⁹). A transbronchial lung biopsy was performed but a dignosis could not be obtained. He underwent left lower lobectomy and lymph node dissection because malignant findings were found in the mass by surgical biopsy. Histologically, the tumor was composed of squamous and giant cell carcinoma and spindle cell formations, and there were also fibrogenic foci and infiltration of lymphocytes. Therefore, he was diagnosed with pleomorphic carcinoma and UIP. Pleomorphic carcinoma following UIP is rare, so we report this case with references to the literature regarding these two diseases.