2008 Volume 22 Issue 5 Pages 770-774
A 64-year-old male received radiotherapy after right upper lobectomy for primary lung cancer invading the chest wall. Six months after the irradiation, he developed radiation pneumonitis in the right apex, and oral prednisolone was administered. Although chest X-ray showed improvement two months later, further chest X-ray analysis and chest computed tomography showed a cavity and surrounding infiltration in the right apex. Sputum culture grew Aspergillus fumigatus, and he was admitted to our hospital. The infiltration rapidly enlarged after the administration of antifungal agents, and complete right pneumonectomy was performed. The histologic findings showed that the fungal hyphae were only on the surface of the cavity wall, and that no fungal invasion of viable lung tissue was seen. The final diagnosis was non-invasive pulmonary aspergillosis. The patient has been followed-up as an outpatient for 10 months, and, so far, there has been no evidence of recurrence of pulmonary aspergillosis or lung cancer. Herein, we report this case with reference to the classification of pulmonary aspergillosis and new antifungal agents.