The Journal of the Japanese Association for Chest Surgery
Online ISSN : 1881-4158
Print ISSN : 0919-0945
ISSN-L : 0919-0945
Localized Castleman's disease of the plasma cell type in the anterior mediastinum
Tomoharu YoshiyaTadasu KohnoSakashi FujimoriMingyon MunHaruka TakeichiJunji Ichinose
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2009 Volume 23 Issue 5 Pages 783-786

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Abstract

A 55-year-old woman became aware of general fatigue in 2003. A health check-up at our hospital revealed a high level of CRP in 2005. Because her symptom had been getting worse, she was admitted to our hospital in 2006. Laboratory data showed anemia, a rise in CRP and IL-6 levels, and hypergammagloblinemia. An enhanced chest CT scan revealed a 1.5 cm, well-circumscribed tumor in the anterior mediastinum surrounded by the chest wall, heart, right lung, and diaphragm. We resected the tumor with surrounding fatty tissue by video-assisted thoracic surgery. Histopathologically, the tumor was diagnosed as Castleman's disease of the plasma cell type, and there were several lymph nodes which had the same features as the main tumor in the en block resected tissue. After surgery, her symptom and abnormal data improved. Cases of localized Castleman's disease are predominantly of the hyaline vascular type. We report a rare case of Castleman's disease of the plasma cell type, which was classified as localized Castleman's disease because only one mediastinal compartment was affected on computed tomography, and there was no clinical or radiographic evidence of additional disease in extrathoracic locations.

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© 2009 The Japanese Association for Chest Surgery
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