Prophylactic administration of corticosteroid and sivelestat sodium hydrate for lung cancer resection with idiopathic interstitial pneumonia

Abstract

This study was performed to analyze the complications and efficacy of perioperative management with corticosteroid and sivelestat sodium to prevent the acute exacerbation of idiopathic interstitial pneumonia (IIP) after lung resection. Methylprednisolone sodium succinate (250 mg, intravenously) was administered to ten cases before the induction of anesthesia and sivelestat sodium (4.8 mg/kg/day, intravenously) was administered before the induction of anesthesia for seven days. Lobectomy with nodal dissection assisted by thoracoscopy was performed in all 10 cases. Sivelestat sodium was discontinued on the third postoperative day in one patient because he had elevations of serum transaminase. No side effects were observed except in this case. No patients with respiratory complications including acute exacerbation of IIP were noted. All 10 cases were followed without local recurrence of lung cancer. We suggest that our perioperative management with corticosteroid and sivelestat is safe and might be effective for the prevention of acute exacerbation.