2015 Volume 29 Issue 6 Pages 678-683
In the present study, we performed a retrospective analysis of 36 patients who underwent pulmonary resection between September 2002 and December 2013 at the Shizuoka Cancer Center Hospital, for metastasis that originated from osteosarcoma and soft tissue sarcoma. The 3- and 5-year overall survival rates of all patients were 70.0 and 65.7%, respectively. The 3- and 5-year overall survival rates of 13 patients with osteosarcoma were 63.6 and 63.6% and those of 23 patients with soft tissue sarcoma were 75.5 and 67.1%, respectively. Univariate analysis indicated that the age at the time of pulmonary metastasectomy (age of <45 vs. ≥45 years: 5-year survival rate of 92.3 and 44.3%, respectively; p=0.03) was the only prognostic factor among such patients. The patients who underwent wedge resection, with a disease-free interval (DFI) of ≥12 months, and those with the lung as the first recurrent site showed a more favorable prognosis, although no significant difference was noted. The findings of the present study indicate that surgical resection of pulmonary metastasis from osteosarcoma and soft tissue sarcoma leads to a favorable prognosis, particularly in patients who are younger, undergo wedge resection, have a longer DFI, or in whom the lung is the first recurrent site. Furthermore, repeat pulmonary metastasectomy in certain patients may improve survival.
