The Journal of the Japanese Association for Chest Surgery
Online ISSN : 1881-4158
Print ISSN : 0919-0945
ISSN-L : 0919-0945
Induction chemoradiotherapy for local advanced non-small-cell lung cancer
Teruhisa SakuraiShoji OuraTatsuya YoshimasuHirokazu TaninoKenji MatsuyamaFuminori OhtaYasuaki Naito
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2001 Volume 15 Issue 5 Pages 538-543

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Abstract

Sixteen patients with operable local advanced non-small cell lung cancer underwent concur rent induction chemoradiotherapy (CCRT) and surgical resection. The patients consisted of 15 males and one female (average age 56 years). Six had sqamous cell carcinomas, three adenocarcinomas, one adenosquamous carcinoma, one large cell carcinoma, one large cell neuroendocrine carcinoma and four were histologically undecided. Seven had apical invading lung cancer, four extensive chest wall invading, three mediastinal invading and two bulky N2. Major chemotherapy regimens included cisplatin 20 mg/m2 on days 1-5 and 29-33, and etoposide 32 mg/m2 on days 1-5 and 29-33. Radiotherapy (40 Gy in 20 fractions) began on day 1. The objective response rate was 69%, with 11 partial responses, without complete response. Operations were performed four weeks after CCRT. No treatment-related mortality was noted. Pathological examination of the surgical specimens showed Ef. 3 in 8 (50%), Ef. 2 in 6 (36%) and Ef. lb in 2 (12%). The overall survival rates by the Kaplan-Meier method were 57.1% and 28.6% at 3 and 4 years, with a median follow-up time of 24 months. These results suggest that CCRT for local advanced non-small-cell lung cancer is an effective induction therapy.

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