Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)
Online ISSN : 1882-4781
Print ISSN : 1340-2242
ISSN-L : 1340-2242
Case Report of a Sigmoid Colon Perforation after Treatment with Nonsteroidal Anti-inflammatory Drugs in a Patient with Recurrent Breast Cancer
Masato YamazakiHideki YasudaKeiji KodaTohru TezukaChihiro KosugiMaki SugimotoYoshihisa WatayoReiko OtakiShuji NakaTomohiro TakenoueHidenori TakahashiNobuo FukeHidetoshi Shiga
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Keywords: NSAIDs
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2007 Volume 27 Issue 4 Pages 619-622

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Abstract

A 55-year-old woman with successive breast cancer recurrences underwent an emergent Hartman's operation for the treatment of pan-peritonitis arising from a large sigmoid colon perforation. Multiple large and amorphous ulcers were observed throughout the sigmoid colon, one of which was 5×2.5 cm in size. Microscopic findings showed nonspecific inflammation and ulcers without atypia, vascularitis or granulomas. A severe pain in her neck and shoulders had required treatment with morphine and diclofenac sodium suppository (25 mg, 3 to 4 times a day for 26 days). The latter agent was thought to be the cause of the ulcer perforation. She survived septic shock, DIC and breast cancer recurrences for five months without becoming bedridden.

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© 2007 Japanese Society for Abdominal Emergency Medicine
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