Japanese Journal of Forensic Science and Technology
Online ISSN : 1881-4689
Print ISSN : 1880-1323
ISSN-L : 1880-1323
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Characterization and differentiation of positional isomers of fluoro-fentanyl analogs by a combination of instrumental analyses
Tatsuyuki KanamoriYuko T. IwataHiroki SegawaTadashi YamamuroKenji KuwayamaKenji TsujikawaHiroyuki Inoue
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2019 Volume 24 Issue 2 Pages 123-133

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Abstract

 The isomers of fluoro-butyrylfentanyl, fluoro-isobutyrylfentanyl, and fluoro-methoxyacetylfentanyl, in which the position of fluorine on the N-phenyl ring varies, were synthesized, characterized, and differentiated by infrared (IR) spectroscopy, liquid chromatography/mass spectrometry (LC/MS), and gas chromatography/mass spectrometry (GC/MS). The isomers could be clearly differentiated by their IR spectra. In the LC/MS chromatograms, the separation of the fluoro-butyrylfentanyl and fluoro-isobutyrylfentanyl isomers was insufficient. However, in the GC/MS extracted ion chromatograms, all compounds were completely separated. The LC/MS and GC/MS mass spectra of the isomers were similar, demonstrating that it is difficult to distinguish the positional isomers of fluorinated fentanyl analogs by their mass spectra.

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© 2019 Japanese Association of Forensic Science and Technology
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