Automated Synthesis of a Tri-branched Pentasaccharide: the Application of the Uni-chemo Hydroxyl Protection Method to the Automated Synthesis of Oligosaccharides

Abstract

A special hydroxyl protecting group, the uni-chemo hydroxyl protection (UCHP), was applied to automated oligosaccharide synthesis. The UCHP is a newly developed hydroxyl protecting group, which is comprised of oligomeric amino acid derivatives. The UCHP method is able to deprotect one hydroxyl after another, selectively, by repeating a simple deprotection protocol. The use of the UCHP group facilitated the automated synthesis of a tri-branched pentasaccharide.