Journal of Applied Glycoscience
Online ISSN : 1880-7291
Print ISSN : 1344-7882
ISSN-L : 1344-7882
Regular Papers
Effect of Different Types of Cyclodextrins on Gastrointestinal Absorption of α-Lipoic Acid in Rats and Humans
Hideki TakahashiEriko KishinoKatsuhiko MikuniYoshihiro KiuchiHidehiko BeppuHideto OkazakiKan ShimpoShigeru Sonoda
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2012 Volume 59 Issue 3 Pages 97-103


Powders of α-lipoic acid (ALA)/cyclodextrin (CD) complexes containing 9-24% (w/w) ALA were prepared to improve the gastrointestinal absorption of ALA. ALA and the ALA/CD complexes, corresponding to 30 mg/kg of body weight of ALA in rats and 600 mg of ALA in humans, were orally administered under fasting conditions. In rats, the area under the ALA plasma concentration/time-course curve from 0 to 3 h (AUC 0-3 h) for the ALA/G2-β-CD® complex was larger than that for ALA alone. In humans, after administration of 3 ALA/CD complexes with γ-CD, G2-β-CD® and Isoeleat®P, the ALA plasma concentration value 0.5 h after administration of the ALA/G2-β-CD® complex was significantly higher (p < 0.05) than that for ALA alone, and the AUC 0-3 h value for the ALA/G2-β-CD® complex was 1.4 times larger than that for ALA alone, although the difference was not significant. We suggest that the water-soluble ALA/G2-β-CD® complex powder can enhance ALA absorption in rats and humans.

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© 2012 by The Japanese Society of Applied Glycoscience
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