Journal of Applied Glycoscience
Online ISSN : 1880-7291
Print ISSN : 1344-7882
ISSN-L : 1344-7882
D-Allose, a stereoisomer of D-glucose, extends the lifespan of Caenorhabditis elegans via sirtuin and insulin signaling
Tomoya ShintaniHirofumi SakoguchiAkihide YoshiharaKen IzumoriMasashi Sato
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JOURNAL FREE ACCESS Advance online publication

Article ID: jag.JAG-2019_0010

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Abstract

D-Allose (D-All), C-3 epimer of D-glucose, is a rare sugar known to suppress reactive oxygen species generation and prevent hypertension. We previously reported that D-allulose, a structural isomer of D-All, prolongs the lifespan of the nematode Caenorhabditis elegans. Thus, D-All was predicted to affect longevity. In this study, we provide the first empirical evidence that D-All extends the lifespan of C. elegans. Lifespan assays revealed that a lifespan extension was induced by 28 mM D-All. In particular, a lifespan extension of 23.8% was achieved (p < 0.0001). We further revealed that the effects of D-All on lifespan were dependent on the insulin gene daf-16 and the longevity gene sir-2.1, indicating a distinct mechanism from those of other hexoses, such as D-allulose, with previously reported antiaging effects.

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© 2019, by The Japanese Society of Applied Glycoscience
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