Effects on ES Cell Differentiation on the Corroded Surface of Four Silver Alloys for Dental Use

Abstract

Dental silver alloys, such as gold-silver-palladium and silver-tin alloys, are frequently used in dental practice. These alloys are examined for biological safety as medical equipment. However, their embryotoxicity in normal newborns has not been investigated. We have reported the embryotoxicity risks of alloys upon their corrosion in the oral cavity, which are different from those of their composition metals. In the present study, four types of silver alloys were examined for ES cell differentiation on their surfaces corroded with human or artificial saliva. In addition, the alloy surfaces were examined by physical scratching and further erosion in dilute hydrochloric or sulfuric acid, because the dental gold-silver-palladium alloy surfaces are resistant to natural corrosion. As a result, chemicals generated upon corrosion of the four kinds of dental silver alloys may have embryotoxicity risks, unlike those immediately after casting.